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NICD then translocates to the nucleus, where it converts the C-promoter binding factor-1 (CBF-1) complex from a transcriptional repressor to an activator, promoting the expression of Notch target genes

This zone comprises the glycocalyx, plasma membrane, surface-connected canalicular system, membrane receptors (e.g., integrins, glycoprotein Ib-IX-V), and the submembrane cytoskeleton [25]

Stability, degradation and regeneration concerns Over extended periods, GO may degrade via photocatalytic processes due to UV exposure, heat, and several chemicals, losing its valuable properties 315

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